Dedicated to Helping People Move
Our mission is to motivate people living with paralysis to move. We study cutting-edge technologies that integrate rehabilitation and engineering principles to restore independence in persons dealing with catastrophic injury to their nervous system.
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Into The Tech: INSPIRE Lab at Spaulding
Take a look below at the studies we have right now. Press the contact button at the bottom of this page to reach out to us.
Intermittent Hypoxia-Induced Recovery of Overground Walking of Persons with Subacute SCI
Can acute intermittent hypoxia (AIH) help recover lower extremity function and walking ability after SCI?Learn More
Combinatorial Treatment of Acute Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Improve Hand Function in People with Cervical SCI
Is AIH and non-invasive electrical stimulation with training helpful for recovering upper extremity function with training after SCI?Learn More
Clinical Assessment of Upper Extremity Performance in Individuals with SCI Using the LIFT System to Deliver Non-invasive Electrical Spinal Stimulation (ARC Therapy)
Is non-invasive electrical stimulation helpful for recovering upper extremity function with training after SCI?Learn More
Spinal Cord Injury (SCI) Biorepository
Can your genome be used to target medications and therapies after SCI?Learn More
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Daily acute intermittent hypoxia combined with walking practice enhances walking performance but not intralimb motor coordination in persons with chronic incomplete spinal cord injury
Persons living with incomplete spinal cord injuries (SCI) often struggle to regain independent walking due to deficits in walking mechanics. They often dedicate many weeks of gait training before benefits to emerge, with additional training needed for benefits to persist. Recent studies in humans with SCI found that daily bouts of breathing low oxygen (acute intermittent hypoxia, AIH) prior to locomotor training elicited persistent (weeks) improvement in overground walking speed and endurance. AIH-induced improvements in overground walking may result from changes in control strategies that also enhance intralimb coordination; however, this possibility remains untested. Here, we examined the extent to which daily AIH combined with walking practice (AIH + WALK) improved overground walking performance and intralimb motor coordination in persons with chronic, incomplete SCI.Read More
Daily acute intermittent hypoxia to improve walking function in persons with subacute spinal cord injury: a randomized clinical trial study protocol
Restoring community walking remains a highly valued goal for persons recovering from traumatic incomplete spinal cord injury (SCI). Recently, studies report that brief episodes of low-oxygen breathing (acute intermittent hypoxia, AIH) may serve as an effective plasticity-inducing primer that enhances the effects of walking therapy in persons with chronic (> 1 year) SCI. More persistent walking recovery may occur following repetitive (weeks) AIH treatment involving persons with more acute SCI, but this possibility remains unknown. Here we present our clinical trial protocol, designed to examine the distinct influences of repetitive AIH, with and without walking practice, on walking recovery in persons with sub-acute SCI (< 12 months) SCI. Our overarching hypothesis is that daily exposure (10 sessions, 2 weeks) to AIH will enhance walking recovery in ambulatory and non-ambulatory persons with subacute (< 12 months) SCI, presumably by harnessing endogenous mechanisms of plasticity that occur soon after injury.Read More