Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease

This article presents a comprehensive review of the promising use of mild acute intermittent hypoxia (AIH) as a therapeutic treatment to improve movement in people with spinal cord injury. It also highlights the gaps in knowledge about therapeutic AIH that require attention for it to be successfully translated from an experimental method to use in the clinic. Dr. Vose describes the AIH knowledge gains and gaps within a “bench-to-bedside” model of scientific discoveries: innovation, translation, optimization, and application. More studies that test AIH dosages, safety, individual response differences, and outcomes with concurrent therapy are recommended to fill the gaps.

Exp Neurol. 2022 Jan;347:113891. doi: 10.1016/j.expneurol.2021.113891. Epub 2021 Oct 9. PMID:34637802 | PMC:PMC8820239 | DOI:10.1016/j.expneurol.2021.113891